Sorry if this is nosy, but can you elaborate a bit on that? All presses work, it comes down to ergonomics and individual preferences, do you use a C press of some sort? Good one you for keeping going on reloading.
In the process of breaking my neck a couple decades ago, I managed to crush the ulnar nerve on the right side, and get what they call a "double-crush" injury on the left radial and ulnar nerves. Right side recovered fairly well, left side was partial. In some arm/hand positions it doesn't work well. I gave up on the Dillon 550 and O-frames when I realized I was doing almost all operations with my right hand. (That's why the Dillon and Rock Chucker were at a friend's house when he passed away, and why I don't mind their loss.)
I do most of my loading these days on C-presses, a turret, and a hand press. If I don't swap it off first, I'll eventually try out that C-H inline progressive I picked up.
Honestly, it bothered me more when I couldn't rack the slide on my beloved 1911s. I've known several guys who load fine with one hand (I've taught a couple of 'em). Just a matter of picking your equipment and knowing what works for you.