I have been rather successful using cast in the Hornet, but had a pretty limited scope for what I wanted to do with it. If you're wanting to approach full Hornet loads or shoot at 100 yards, I can't help you.
I got my first Hornet out of frustration over the rim fire shortage a few years ago. After playing a little with some standard Lyman molds, I bought a four cavity NOE of their 45 grain WFN with all plain bases. These shoot squirrel head accurate from my old Savage 219 using two grains of Bullseye. In fact, that 219 has become my favorite squirrel rifle and just generally poking around in the woods gun.
A Stevens 322 came along shortly after, and I bought one of the limited production Lee Bators Midsouth used to sell (the one now is not the same). Suprisingly, due to its short design, it stabilized in the old twists and I cast a bunch up, very soft, gas checked them and shoot them with 6 grains of 2400 in the Stevens which won't feed that WFN NOE. Also very accurate at realistic small game ranges.
I use a set of the Lee collet neck size dies and a Lee Universal expander. I have not found the Hornet to be any more difficult to load than any other cartridge. Hope this helps.