I did a stint with heavy loads in one of the first 7-1/2 in. 45 Colt Redhawks made. I also had an identical Redhawk in 44 Mag at the time as well, plus a 5-1/2 in 41 Mag Redhawk. I was hitting a level with the 45 Colt that I didn't believe I could match with the 44 Mag, my real limitation was the bullet moulds available in comparable weights at the time.
I got a bit nervous when I discovered that my 45 Colt velocities were in the load ranges of the custom five-shot guns, and I backed off fast & hard, around 1350+ with Lymans 452651 bullet (going by memory). The real issue came to light one day when I realized that I had never weighed my bullets for the 45, and I found that instead of weighing 325 gr, my bullets were 340+ grains. Apparently I had a mould that was cut for lino, and I was feeding it wheelweight bullets instead. Anyway, the Redhawk was unfazed by the ordeal, but was no fun to shoot like a normal, sane human, and I traded it off after it sat in my safe for a year or better. The guy who bought it still raves at its accuracy. I've tried to buy it back numerous times, but to no avail.
This left the 44 mag gun to do most of the work, hamstrung in my eyes by the difficulties I had finding proper moulds for it that weighed over 300 gr. Veral was still a guest at Club Fed at the time, and the only other real source was NEI, but I was resistant about them in those days, probably because Elmer Keith and Skeeter Skelton hadn't blessed them yet. I now have moulds for this weight class, including the NEI/SSK design, and Lymans 429649 (which requires lapping before use). There are others, but the moment is passed. Now the 44 mag gets MP Keith design, or LBTs 280 gr LFN.