think of your powders in steps.
red-dot,,,, unique,,,, 2400,,,, h-110.
it works the same in pistol calibers and in rifle cases.
your bound by a maximum pressure,, no way around that.
so all you can work with is the amount of time the powder pushes on the bullet.
that translates into velocity windows.
900 fps,,, 1200 fps,, 1600 fps,, 1900 fps.
so what you end up with is a powder running into a pressure wall right about the time it hits half way through a velocity step, and your left deciding to step back a little or moving on to more of a slower powder which starts the whole thing all over again.