When we talk of bullet performance on "free range drain clogs and hair balls" we walk a fine line trying to find an optimum balance between expansion and penetration.
My experience with a pajama clad, rifle toting, heavily medicated mental patient: involved two 4" Model 66/19 S&W's mine with R/P158gr JHP's (the old 1975 era full power .357 Mag loading) and a fellow officer carrying Supervel 110gr JHP .357 magnum ammunition from the same era. My 158's showed minimal expansion, but penetrated a forearm and torso, a metal filing cabinet, and interior wall w/2 layers of drywall, and exterior wall of drywall, insulation sheathing and brick veneer....as far as anyone can tell they might still be flying. The Supervel's splashed on the surface creating ugly wounds perhaps 4-5" deep. The guy took 7 solid upper torso hits and never blinked, he smiled, turned around and raised his rifle pointing at my chest with his remaining good arm, then collapsed dead.
Both loads worked, eventually, but neither instilled any confidence. My answer was a compromise of WW 140gr. Silvertips in the .357Magnum until I obtained and qualified with a 45acp. My point in all this is the two similar handguns in the same caliber had the opposite performance in the same circumstance. The difference was ammo. We need enough penetration to reach and destroy vitals from any angle, and a big enough hole to maximize that damage. It is a balancing act between expansion (or big enough diameter to start with) and penetration. In any event it has to be delivered accurately and as quickly as possible.