Yes, just follow the book loads and you'll probably find that you like it as much as Unique for this application.
I use it for 148 gr. WCs and 158 gr. RFNs/SWCs. I like it for 750 fps to 1kfps. You can get more out of it, but it seems to be sort of a sweet spot.
I've also experimented with HP38/W231 in a lot of other cast handgun and rifle loads where I would normally use Unique and it has not once disappointed me. In the 222R, it actually gave me better accuracy with 50 and 55 gr. cast than my go-to "squirrel-load." at least in my current 222. I originally bought it for the 45 ACP, but started experimenting with it after I dropped that cartridge from my lineup. Also great in the 44 Special.