I have more 22 LR handguns than rifles these days. 3 long ones--a Winchester bolter Model 67 single-shot that has factory irons and shoots decently, about 7/8" at 50 yards. Another iron-sighter is my 1965-vintage Winchester 290; it's one of my Steak & Lobster Cotillion Debutante 22 LRs, along with the SIG Mosquito. Only CCI will do in either arm, but both do good things when fed what they want. Last but not least is a well-used Ruger 10/22 that came home with me in the late 1990s from a large Westminster gun store (it's name escapes me) for the princely sum of $65. It looked a little rough, but once cleaned up was actually still tight and decent, with a mirror bore.
My original plan was to Barbie-Doll the receiver into a Volquartsen truck-axle barrel iron-sighter for the long-departed Burrito Shoot 22 LR days, but on a Burrito Shoot day I ran some of the 290's Mini-Mags through it--DANG, this little thing can SHOOT. It shot the humbler grades of cheep 22 LR reliably, it eats anything. Scrap the Barbie-Doll project, I mounted a 4X scope on it and so it has stayed for 25 years--ugly enough to repel kids and grandkids from doing to it what they've done with about a half-dozen other 10/22s over the years--TAKE THEM HOME WITH THEM--and accurate enough to make Dad/Grandpa happy.
25 years ago, discount 22 LR ammo used to be decent and reasonably accurate. These days, not so much--it doesn't feed, it shoots dirty, it throws fliers when it does feed and fire. Since about 2005 it has been 'All CCI all the time' at my place. Even their bargain-basement Blazer 22 LR feeds and fires in The Debutantes. CCI Mini-Mag and SGB are my go-to fodder for 22 LR on varmints these days.