There isn't any real difference in weight between a Blackhawk in 45 and a GP100 in 44 in similar barrel lengths, or a Smith for that matter in steel. The Security Six shaves close to half a pound off. The Charter BD Target weighs half as much as the GP100, 22 vs 40ish oz, at the cost of one round and a lot of reputation.
If you intend to actually carry a gun all day, half a pound or more adds up real fast. Wearing a "Bat Utility Belt" for 8-16 hours at a time that weighed 5 to 7 lbs for many years, I got all the experience I wanted in that line. If you are just going to wear a standard every day belt and not a real
Sam Brown type gun belt and pack a 40 oz plus gun all day, consider adding some suspenders. Seriously, they help a lot.