Has the mould, has the gun... Why not? I could do anything I need, to include deer hunting if I had time, with the 200 grain RFN with a generous meplat, but the 429421 shoots a teeny bit better and seems amenable to any (reasonable) charge of any powder I use.
Might have trouble getting the rear sight low enough though.
My front sight was too low right out of the box, even for factory-level 250 SWCs. Warm them up a little and it was worse. The RDO 265 - forget it. It was shooting 8" high at 20 yards. Reducing bullet weights wasn't nearly enough. Asked Ruger to address this when they took the gun back to correct two chambers radially out of synch with the others and they replaced the gun, but ignored the sight. Same problem.
I worked the top of the rear sight blade down to almost flush with the body of the sight and deepened the notch, still have the sight bottomed out, but at least I hit to POA now with 200 RFNs and 250 SWCs.
This was a problem with SOME of the Flat Top 44 Specials, but not all. I got two in a row - one original Lispey's from 2009, and a standard production unit about 2014.
Shooting the RCBS 300 and LEE 310 from a 7.5" OM SBH, I could not get the rear sight low enough - 10" to 12" high at 30 yards with the rear sight bottomed out.