Will have to look that up. I never considered 4227 hard to ignite but it may be?
I have had IMR 4227 fail to light in the 35 Maximum using a full case, 180 grain cast with a gas check, plenty of "neck" tension and a firm crimp using Wolf Small Rifle "Magnum" primers. There's nothing "magnum" about these primers and they differ from regular primers only in that they have a tougher cup to prevent slam fires in autos (ARs). These primers have ignited reliably in the 223, 222, 300 BLK, 357 Mag and 357 Max in numerous rifles and at least one revolver (SP101) in spite of the tougher cup.
When these failed to ignite the powder, I was using a Handi-Rifle with a factory hammer spring and had no previous issues with primers failing to light. There has never been any evidence of light primer strikes in any of the guns I use them in (Handi-Rifles, TC Contenders, Ruger 77/357, SP101, Rossi 92, CZ 527s)
When I pulled down the three which failed to fire (from a batch of forty) in the 357 Max case using IMR4227, I found the aluminum gas checks had some gray/blak soot and minor impressions of the powder kernels on them. Inspecting the primers indicated that they had in fact lit - they just hadn't lit the powder. I had not gotten to the chronographing stage of that development so can't asy what the extreme spread was. Accuracy was neither terrible nor great or I'd have remembered that. It was not particularly cold out - at least above freezing.
That's the only time I've ever had that happen and had never had any issue getting IMR 4227 to light using non-magnum primers, but it got my attention because having the primer light but not igniting the primer is dicey. Had they been light primer strikes, I wouldn't have though much of it, but a "misfire" could really be a hangfire and in a break-action, it could be a bad day on either end of the rifle if you open it at just the wrong moment.
