I havent really seen large differences in powders with the few small caliber barrels I have loaded for, 748, H322/335, 2200, 2230, 4198, Benchmark, AR Comp. All have done a good job. Last two are newest to my use but have really shined, especially in the Grendel. The 223's have always come back to H322 and 748. Some crazy good groups have been shot in bolts, ar's and a single shot rifles. Even my contender pistol have shot them very well.
When I got a 25/45 (24" HB Sharps barrel) I saw a picky barrel. Everything shot acceptable, H335 was first to see consistant sub MOA groups but only with a 90g Sierra... But when I found some AA220, wow, it was hands down preferred and in reading many found same results. Most any loading with bullets 87-110 shot sub moa for me using aa2200, good velocity as well.
The lil Grendel shows favor for a few but also isnt overly picky. I also tried 2520 powder with some bullets its a very impressive little caliber. In both a bolt and MSR. I hover around 120g in this one as lighter simply pale to accuracy of heavier. But 85/90g bullets have shot moa. As I have smaller guns that do better, I stick with 120 ish.
The littler calibers like 22 Hornet & Bee 4198 is a shinning star. I did find little gun and a 35 Vmax bullet in the hornet from one H&R SS rifle was its only load that shot really well. 4198 just shines in the Contender, H&R and Winchester 43's.
But I consider all these barrel accuracy issues more then powder. Powder surely can be different Thats why there are lots recorded. Powder is a better constant at least in my perception.
CW