I was on a pretty good run for about ten years only using cast bullets on deer and usually "small bores" of .30 caliber. I used a .45-70 once, mostly because I wanted to use one of my Dad's cast bullets and he wasn't a hunter, so most of his were too hard and of nose designs that I didn't feel would transfer energy well.
Got lazy a couple of years ago, didn't really have a new cast rifle worked up, looked at my old Model 70 in the rack and remembered it did well with almost a max load of 760 and 165 grain Sierra Game Kings, so got a bok of the Sierras and loaded up a few, which the rifle still did shoot very well. Holy cow, but I had forgotten how load a full up '06 is and how much it kicks! ANyway, sat on the edge of a field and had a doe present a good shot maybe 150 yards so I took it. She was on the edge of a tree line, so she made it into cover. Very destructive double lung shot, but she still went just as far as I was used to seeing with cast (granted, the cast shots were all closer) and I had to look around a while to find her.
Been using that 6.5 Ruger American the past few years here on my own small place, nowhere you could get a shot that long. It works, but I really do believe that what most people hunt deer with is overly powerful for the task, I'll just caveat that I think one needs enough bullet mass to get the job done and I won't be using .22 centerfire. They are deer, not dinosaurs. That jacketed load in the '06 just seems like a ridiculous overkill to me at the time.