So the question about auto cartridges in wheelguns is really a question about moonclips.
For me, the answer comes down to "what is the gun used for"? As much as I like moonclips for the speed of loading and unloading - A bent moonclip will tie up the action. So for me, No Moonclips on a Primary Self-defense weapon. Or in other words, no Moonclips on guns that might need to be reloaded during combat.
Generally speaking the moonclip in the gun will be fine, it's the spares carried that are susceptible to damage. A speedloader such as a Safariland or HKS will take a tremendous amount of abuse before it will fail to function. It doesn't take much to bend a moonclip and if a bent moonclip makes it into the gun, there's a very high probability it will tie up the gun.
The other issue is how the cartridge headspaces in the chamber. Some revolvers set up for rimless auto cartridges will headspace the cartridge on the case mouth and those guns will reliably fire the cartridge even without moonclips in place (ejecting the spent rounds without a moonclip is another story). Some setups must have the moonclip to headspace the cartridge and they will not reliably fire without the moonclip present.
Now, for recreational shooting and competition - Moonclips are awesome!